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- Title
Wait and see: a case of EBV + cutaneous extranodal NK/T-type lymphoma with indolent behaviour.
- Authors
Aromolo, Italo Francesco; Pescia, Carlo; Simeoli, Domenico; Violetti, Silvia Alberti; Ferla, Valeria; Rossi, Francesca Gaia; Croci, Giorgio Alberto
- Abstract
Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 − /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.
- Subjects
EPSTEIN-Barr virus; MANTLE cell lymphoma; LYMPHOMAS; CANCER chemotherapy; WATCHFUL waiting; EXTRANODAL NK-T-cell lymphoma
- Publication
Virchows Archiv: European Journal of Pathology, 2024, Vol 484, Issue 6, p1029
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-023-03681-9