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- Title
Synthesis and radical scavenging of novel magnolol derivatives.
- Authors
Wang, Yvonne; Li, Chi-Yuan; Lin, I-Hshin; Lee, An-Rong; Hu, Ming-Kuan
- Abstract
ABSTRACT We have investigated the developdment of potential antioxidants based on magnolol, a naturally occurring biphenolic obtained from the bark of Magnolia officinalis. A series of aminomethylated derivatives of magnolol were synthesized under the aromatic Mannich reaction. In-vitro testing for diphenyl- p-picrylhydrazyl (DPPH) scavenging and chemiluminescence assays in whole cell models revealed that the pyrrolidyl-containing magnolols ( 2b (5,5′-diallyl-3-(pyrrolidin-1-ylmethyl)-biphenyl-2,2′-diol), 3a (5,5′-diallyl-3,3′-bis-(pyrrolidin-1-ylmethyl)-biphenyl-2,2′-diol) and 4c (5,5′-diallyl-3-(morphorin-4-ylmethyl)-3′-(pyrrolidin-1-ylmethyl)-biphenyl-2,2′-diol)) displayed promising free radical scavenging effects as compared with magnolol. The results from compound 4c indicated that the naturally occurring component was suitable to be a lead compound toward promising antioxidants.
- Publication
Journal of Pharmacy & Pharmacology, 2002, Vol 54, Issue 12, p1697
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/002235702360