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- Title
Prostate Saturation Biopsy following a First Negative Biopsy: State of the Art.
- Authors
Maccagnano, Carmen; Gallina, Andrea; Roscigno, Marco; Raber, Marco; Capitanio, Umberto; Saccà, Antonino; Pellucchi, Federico; Suardi, Nazareno; Abdollah, Firas; Montorsi, Francesco; Rigatti, Patrizio; Scattoni, Vincenzo
- Abstract
Introduction: Saturation prostate biopsy (SPBx) has been initially introduced to improve prostate cancer (PCa) detec-tion rate (DR) in the repeat setting. Nevertheless, the optimal number and the most appropriate location of the cores, to-gether with the timing to perform a second PBx and the eventual modification of the PBx protocols according to the different clinical situations, are matters of debate. The aim of this review is to perform a critical analysis of the literature about the actual role of SPBx in the repeat setting. Materials and Methods: We performed a systematic review of the lit-erature since 1995 up to 2011. Electronic searches were lim-ited to the English language, using the MEDLINE database. The key words 'saturation prostate biopsy' and 'repeated prostate biopsy' were used. Results: SPBx improves PCa DR if clinical suspicion persists after previous biopsy with nega-tive findings and provides an accurate prediction of prostate tumor volume and grade, even if the issue about the number and locations of the cores is still a matter of debate. Conclu-sions: At present, SPBx seems to be really necessary in men with persistent suspicion of PCa after negative initial biopsy and probably in patients with a multifocal high-grade pros-tatic intraepithelial neoplasia or atypical small acinar prolif-eration. In the remaining situations, adopting an individual-ized scheme is preferable.
- Subjects
DIAGNOSIS; PROSTATE cancer; BIOPSY; MEDICAL databases; ELECTRONIC information resource searching; SYSTEMATIC reviews; CRITICAL analysis
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 2, p126
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000339521