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- Title
Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11.
- Authors
Ugrankar, Rupali; Theodoropoulos, Pano; Akdemir, Fatih; Henne, W. Mike; Graff, Jonathan M.
- Abstract
In mammals, blood glucose levels likely play a role in appetite regulation yet the mechanisms underlying this phenomenon remain opaque. Mechanisms can often be explored from Drosophila genetic approaches. To determine if circulating sugars might be involved in Drosophila feeding behaviors, we scored hemolymph glucose and trehalose, and food ingestion in larvae subjected to various diets, genetic mutations, or RNAi. We found that larvae with glucose elevations, hyperglycemia, have an aversion to feeding; however, trehalose levels do not track with feeding behavior. We further discovered that insulins and SLC5A11 may participate in glucose-regulated feeding. To see if food aversion might be an appropriate screening method for hyperglycemia candidates, we developed a food aversion screen to score larvae with abnormal feeding for glucose. We found that many feeding defective larvae have glucose elevations. These findings highlight intriguing roles for glucose in fly biology as a potential cue and regulator of appetite. Rupali Ugrankar et al. show that Drosophila larvae with high levels of circulating glucose, but not trehalose, don't eat much. This study suggests that circulating glucose communicates with insulin signaling and the sodium/solute co-transporter SLC5A11 in the brain to suppress larval appetite.
- Subjects
DROSOPHILA; INSECT larvae; HYPERGLYCEMIA; APPETITE
- Publication
Communications Biology, 2018, Vol 1, Issue 1, pN.PAG
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-018-0109-4