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- Title
Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis.
- Authors
Ueno, Hiromichi; Miyamoto, Tetsu; Morimoto, Hiroyuki; Sanada, Kenya; Furuno, Ikutaro; Nakazono, Kazutoshi; Hasegawa, Emi; Kuma, Akihiro; Oginosawa, Yasushi; Tsuda, Yuki; Araki, Masaru; Tamura, Masahito; Ueta, Yoichi; Otsuji, Yutaka; Kataoka, Masaharu
- Abstract
Background: In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected to be improved biocompatible. This study evaluated the biocompatibility of B/L-PDFs by analysis on the profile of angiogenesis-related proteins in drained dialysate of patients undergoing PD. Methods: Concentrations of 20 angiogenesis-related proteins in the dialysate were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array and were compared between B/L-PDFs and conventional lactate-buffered neutral PDFs (L-PDFs). Results: The expression of growth-related oncogene (GRO α/β/γ), which belongs to the CXC chemokine family, decreased significantly after use of the B/L-PDFs compared to the L-PDFs (P = 0.03). The number of the proteins with lower level in the B/L-PDFs compared with L-PDFs was significantly negatively correlated with the PD duration (Spearman ρ = − 0.81, P = 0.004). Conclusion: This study suggested that B/L-PDFs are more biocompatible than conventional PDFs.
- Subjects
STATISTICS; ONCOGENES; PERITONEAL dialysis; QUANTITATIVE research; BIOMEDICAL materials; COMPARATIVE studies; BICARBONATE ions; DRUGS; RESEARCH funding; HEMODIALYSIS; VASCULAR endothelial growth factors; CHEMOKINES; DATA analysis; LACTIC acid
- Publication
Renal Replacement Therapy, 2021, Vol 7, Issue 1, p1
- ISSN
2059-1381
- Publication type
Article
- DOI
10.1186/s41100-021-00344-w