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- Title
Changes in serum concentration of rilpivirine in an HIV-infected patient treated with a combination therapy of hemodialysis and peritoneal dialysis.
- Authors
Oshiro, Nanako; Kohagura, Kentaro; Tsuneyoshi, Shoji; Tateyama, Masao; Zamami, Ryo; Uehara, Hitoshi; Fujita, Jiro; Ohya, Yusuke
- Abstract
Background: To our knowledge, there are no preexisting reports concerning rilpivirine (RPV) removal by hemodialysis and peritoneal dialysis. Case presentation: This study aimed to evaluate the effect of hemodialysis and peritoneal dialysis on plasma concentrations of RPV in a 45-year-old man infected with HIV and exhibiting end-stage renal disease (ESRD). The extraction ratio of RPV by hemodialysis was 4.5%. Plasma concentrations of RPV remained far above the protein-binding-adjusted inhibitory levels during a combination therapy of hemodialysis and peritoneal dialysis. Our results suggest minimal RPV removal via hemodialysis and peritoneal dialysis with no specific dosage adjustments required in an HIV-infected patient undergoing this combination therapy. Conclusion: In conclusion, this study showed that RPV administered without dose adjustment resulted in steady-state plasma drug concentration in an HIV-infected patient treated with a combination therapy of hemodialysis and peritoneal dialysis.
- Subjects
HIV-positive persons; HIV infections; CHRONIC kidney failure; RILPIVIRINE; HEMODIALYSIS; COMBINED modality therapy
- Publication
Renal Replacement Therapy, 2020, Vol 6, Issue 1, p1
- ISSN
2059-1381
- Publication type
Article
- DOI
10.1186/s41100-020-00282-z