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- Title
Polo-like kinases and the orchestration of cell division.
- Authors
Barr, Francis A.; Silljé, Herman H. W.; Nigg, Erich A.
- Abstract
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular structures through interactions with phosphorylated docking proteins. Moreover, information is emerging on the substrate specificity of Plks and the role of individual substrates in M-phase progression.
- Subjects
CELL division; MITOSIS; MEIOSIS; CYTOKINESIS; PROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 6, p429
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1401