We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Calcium: Extracellular calcium sensing and signalling.
- Authors
Hofer, Aldebaran M.; Brown, Edward M.
- Abstract
Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular Ca2+ - the extracellular calcium-sensing receptor - has opened up the possibility that Ca2+ might also function as a messenger outside cells. Information about the local extracellular Ca2+ concentration is conveyed to the interior of many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning the signalling function of extracellular Ca2+, with particular emphasis on the extracellular calcium-sensing receptor.
- Subjects
CALCIUM; EXTRACELLULAR enzymes; G proteins; PHOSPHOLIPASES; AMINO acids
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 7, p530
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1154