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- Title
The protein import motor of mitochondria.
- Authors
Neupert, Walter; Brunner, Michael
- Abstract
Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works ? a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
- Subjects
PROTEINS; MITOCHONDRIA; BIOLOGICAL transport; CELL physiology; PHYSIOLOGY
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 8, p555
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm878