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- Title
MicroRNA-mediated regulation of T helper cell differentiation and plasticity.
- Authors
Baumjohann, Dirk; Ansel, K. Mark
- Abstract
CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune responses to a wide range of pathogens and are central to the success of vaccines. However, their dysregulation can cause allergies and autoimmune diseases. The CD4+ T cell population is characterized not only by a range of distinct cell subsets, such as TH1, TH2 and TH17 cells, regulatory T cells and T follicular helper cells - each with specific functions and gene expression programmes - but also by plasticity between the different TH cell subsets. In this Review, we discuss recent advances and emerging ideas about how microRNAs - small endogenously expressed oligonucleotides that modulate gene expression - are involved in the regulatory networks that determine TH cell fate decisions and that regulate their effector functions.
- Subjects
T helper cells; CELLULAR control mechanisms; IMMUNOREGULATION; AUTOIMMUNE diseases; GENE expression; PHENOTYPIC plasticity; MICRORNA; OLIGONUCLEOTIDES
- Publication
Nature Reviews Immunology, 2013, Vol 13, Issue 9, p666
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3494