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- Title
Adipokines in inflammation and metabolic disease.
- Authors
Ouchi, Noriyuki; Parker, Jennifer L.; Lugus, Jesse J.; Walsh, Kenneth
- Abstract
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
- Subjects
LIPOTROPIN; METABOLIC disorders; OBESITY; FAT cells; ADIPOSE tissues; TYPE 2 diabetes; LIFE expectancy; INFLAMMATION; PEPTIDE hormones; RESEARCH funding
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 2, p85
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2921