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- Title
Disease-associated functions of IL-33: the new kid in the IL-1 family.
- Authors
Liew, Foo Y.; Pitman, Nick I.; McInnes, Iain B.
- Abstract
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
- Subjects
INTERLEUKINS; RECEPTOR antibodies; ATHEROSCLEROSIS prevention; HELMINTHIASIS; ASTHMA diagnosis; INFLAMMATION; ATOPIC dermatitis; ANAPHYLAXIS; PREVENTION
- Publication
Nature Reviews Immunology, 2010, Vol 10, Issue 2, p103
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2692