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- Title
EXPRESSION ANALYSIS OF INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE-4 (IRAK-4) GENE INMIDGUT OF LIPOPOLYSACCHARIDE INDUCED PENAEUS MONODON.
- Authors
Kumari, Ranjeeta; Bedekar, M. K.; Prasad, K. Pani; Kumar, Kundan; Rajendran, K. V.
- Abstract
Interleukin-1 receptor associated kinase-4 (IRAK-4) has been identified as a central signal transduction mediator of the Toll-like receptor (TLR) and Toll/interleukin-1 receptor (TIR) pathways both in vertebrate and invertebrate innate immunity. To investigate the role of Toll-pathway in innate immune response of shrimp, Penaeus monodon, expression analysis of IRAK-4 gene in mid-gut of LPS induced shrimps wasdone at five time points. Responses of this gene to LPS by Quantitative real time PCR (qPCR) expression analysis of the IRAK-4 gene wasdone in control and LPS induced P. monodon. Mid-gut tissue expressions of theIRAK-4 gene was significantly up regulatedin the LPS induced group. The study indicatedthe critical role of IRAK-4 in gut immunityof P. monodon.
- Subjects
PENAEUS monodon; INTERLEUKIN-1 receptors; TOLL-like receptors; WHITE spot syndrome virus; CELLULAR signal transduction; GENES
- Publication
Journal of Experimental Zoology India, 2019, Vol 22, Issue 2, p707
- ISSN
0972-0030
- Publication type
Article