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- Title
Organization and execution of the epithelial polarity programme.
- Authors
Rodriguez-Boulan, Enrique; Macara, Ian G.
- Abstract
Epithelial cells require apical-basal plasma membrane polarity to carry out crucial vectorial transport functions and cytoplasmic polarity to generate different cell progenies for tissue morphogenesis. The establishment and maintenance of a polarized epithelial cell with apical, basolateral and ciliary surface domains is guided by an epithelial polarity programme (EPP) that is controlled by a network of protein and lipid regulators. The EPP is organized in response to extracellular cues and is executed through the establishment of an apical-basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insight into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.
- Subjects
EPITHELIAL cells; MORPHOGENESIS; EXFOLIATIVE cytology; CELL membranes; CELL polarity
- Publication
Nature Reviews Molecular Cell Biology, 2014, Vol 15, Issue 4, p225
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3775