We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population.
- Authors
McCormack, R M; Maxwell, A P; Carson, D; Patterson, C C; Bingham, A; Savage, D A
- Abstract
Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.
- Subjects
UNITED Kingdom; DNA; GENETIC polymorphisms; GENETICS of diabetes
- Publication
Genes & Immunity, 2001, Vol 2, Issue 4, p233
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6363749