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- Title
Inhibition of vitamin C oxidation by DNA aptamers.
- Authors
Chiu, Alexander S.; Sankarapani, Vinoth; Drabek, Rafal; Jackson, George W.; Batchelor, Robert H.; Yoon-Seong Kim
- Abstract
Vitamin C (ascorbic acid) is not only commercially available as a nutritionally important dietary supplement, but is also used as a stabilizer in a wide range of other products, including beverages, cosmetics and therapeutics, because of its antioxidant properties. However, vitamin C itself undergoes oxidation upon storage, which decreases its efficacy as a stabilizer of other materials and also significantly reduces the shelf-life of products containing it as an active ingredient. Protecting such formulations and products against oxidation-induced degradation would thus be valuable. Here, we report the development of a new DNA aptamer that decreases the rate of oxidation of vitamin C in aqueous solution. We found that the presence of this aptamer reduced the rate of CuSO4-stimulated oxidation of vitamin C by more than 50% in aqueous solution. Furthermore, we also found that the aptamer increased the half-life of vitamin C by up to 1.7-fold in certain commercially available vitamin water formulations. This is the first description of aptamer-based stabilization of a commercially important substance and has significant implications for multiple industries.
- Subjects
VITAMIN C; OXIDATION of DNA; APTAMERS; WATER; THERAPEUTICS; AQUEOUS solutions
- Publication
Aptamers, 2018, Vol 2, p28
- ISSN
2514-3247
- Publication type
Article