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- Title
Psychosis and metabolic syndrome.
- Authors
Froes, V.; Afonso, H.; Carneiro, M.; Esteves, S.; Esteves-Sousa, D.; Gameiro, Z.; Gago, J.
- Abstract
Introduction: Metabolic syndrome has been frequented associated to psychosis, although it is not clear if it's related to both unhealthy life style and antipsychotic medication or if it's previous risk factor. Objectives: Our objective is to review the correlation between Metabolic Syndrome and Psychosis Methods: A non systematic literature search was performed in pubmed, medline, Cocrahne and uptodate, using the key words "Metabolic Syndrome" and "psychosis". Results: Metabolic Syndrome has been clearly associated to second generation antipsychotics mostly clozapine, olanzapine, quetiapine, risperidone by several studies. Despite of that, there have been conducted studies in first psychotic episode that found metabolic alterations, like high insulin resistance and alterations in sphingolipids previous to the introduction of medication. A study found high glucose tolerance when compared to controls. Other study found that first psychosis episode patients have high levels of inflammatory cytokines, like ferritine, plasminogen activator inhibitor-1 (PAI-1), IL 6. In other study the authors concluded that low levels of high-density lipoprotein (HDL) and abdominal perimeter were the best predictors for the developed of metabolic syndrome. There are some studies that report good results in treatment of obesity in schizophrenia patients with topiramate, melatonin and ocytocin. Conclusions: Metabolic syndrome in psychotic patients is a complex area. Alterations in first psychotic episode leads us to re-think metabolic alterations as part of the disease. It is reinforced the importance of prevention and healthy life style. More studies are necessary to better characterize these alterations.
- Subjects
METABOLIC syndrome; PSYCHOSES; PLASMINOGEN activators; INSULIN resistance; HIGH density lipoproteins
- Publication
European Psychiatry, 2020, Vol 63, pS238
- ISSN
0924-9338
- Publication type
Article