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- Title
P01-306-Adhd, gender, and psychiatric comorbidity in a populaiton-based birth cohort
- Authors
Yoshimasu, K.; Barbaresi, W.J.; Colligan, R.C.; Killian, J.M.; Voigt, R.G.; Weaver, A.L.; Katusic, S.K.
- Abstract
Introduction: ADHD is frequently associated with comorbid psychiatric disorders. However, epidemiologic studies in the general population are rare. Objective: To evaluate associations between ADHD and comorbid psychiatric disorders using research-identified incident ADHD cases and population-based controls. Method: Subjects included a birth cohort of all children born 1976-1982 remaining in Rochester, MN after age five (n=5718). Among them we identified 379 ADHD incident cases and 758 age-sex matched non-ADHD controls, passively followed to age 19. Through a systematic, multistaged process, utilizing detailed, routinely collected data, all psychiatric diagnoses confirmed by medical professionals were identified (n=314 ADHD cases, n=712 controls with research authorization). For each psychiatric disorder, cumulative incidence rates for subjects with and without ADHD were calculated; corresponding hazard ratios (HR) adjusted for sex, mothers age/education, were estimated using a Cox model. Associations between ADHD status and Internalizing-Externalizing dimensions were estimated using odds ratios (OR). Results: ADHD was associated with significantly increased risk for adjustment disorders (HR=3.82), conduct disorder/oppositional defiant disorder (HR=9.45), mood disorders (HR=3.57), anxiety disorders (HR=2.95), tic disorders (HR=6.41), eating disorders (HR=5.52), personality disorders (HR=5.49), and substance-related disorders (HR=4.04). When psychiatric comorbidities were classified on the Internalizing-Externalizing dimension, ADHD was strongly associated with coexisting internalizing/externalizing (OR=10.6, vs none), and externalizing-only (OR=10.0), disorders. No significant gender x ADHD interactions were observed. Conclusion: This population-based study confirms that children with ADHD are at significant risk for co-morbid psychiatric disorders. Besides treating the ADHD, clinicians should assess and monitor potential psychiatric comorbidities in children with ADHD.
- Subjects
ATTENTION-deficit hyperactivity disorder; COMORBIDITY; COHORT analysis; EPIDEMIOLOGY; OPPOSITIONAL defiant disorder in adolescence; EATING disorders; PERSONALITY disorders; TIC disorders
- Publication
European Psychiatry, 2011, Vol 26, p308
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(11)72017-X