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- Title
Dietary Tomato Pectin Attenuates Hepatic Insulin Resistance and Inflammation in High-Fat-Diet Mice by Regulating the PI3K/AKT Pathway.
- Authors
Sun, Jing; Wu, Kongyan; Wang, Pan; Wang, Yubin; Wang, Dan; Zhao, Wenting; Zhao, Yuanyuan; Zhang, Chunhong; Zhao, Xiaoyan
- Abstract
Chronic metabolic disease is a serious global health issue, which is accompanied by impaired insulin resistance. Tomato pectin (TP) is a naturally soluble complex hetero-polysaccharide with various biological functions. However, the impact of TP on hepatic insulin resistance in a high-fat diet (HFD) and its potential mechanism remains largely unknown. The results revealed that TP treatment significantly decreased the liver weight, hepatic fat accumulation and hepatic injury in HFD-fed mice. TP also improved fasting blood glucose levels and glucose tolerance in HFD-fed mice. The underlying mechanisms involved in the inflammation, oxidative stress and insulin signaling in the liver were also investigated by RT-qPCR and western blot, which indicated that TP ameliorated hepatic insulin resistance by regulating the PI3K/AKT/GSK-3β pathway, increasing the expression of GLUT4, decreasing the expression of PECK and G6P as well as restoring antioxidant activities and suppressing the inflammation statues in HFD-fed mice. Our data showed that dietary TP has profound effects on hepatic insulin resistance, inflammation and oxidative stress, demonstrating that TP might be a promising therapeutic agent against insulin resistance and related chronic metabolic disease.
- Subjects
PI3K/AKT pathway; INSULIN resistance; METABOLIC disorders; INSULIN; HIGH-fat diet; BLOOD sugar
- Publication
Foods, 2024, Vol 13, Issue 3, p444
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods13030444