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- Title
SUPLEMENTACJA WITAMINY D U PACJENTÓW PO CIĘŻKICH OPARZENIACH.
- Authors
MARKOWSKA, MARTA; MACIEJEWSKA, DOMINIKA; ANWEILER, DARIA; STACHOWSKA, EWA; DEC, KAROLINA; STAROŃ, KRZYSZTOF; KRAJEWSKI, ANDRZEJ
- Abstract
The significance of vitamin D increased when its anti-rickets activity was recognized in the first half of the 20th century. Vitamin D deficiency disturbs the calcium and phosphorus balance, which may result in adult osteomalacia and osteoporosis. This study aims to review literature (2000-2016) concerning the vitamin D level and promote its supplementation in patients with severe burns. Most reports prove that burn patients are suffering from vitamin D deficiency (<30 ng/mL) for months. These patients have an increased need for vitamin D, which is utilized in numerous metabolic processes maintaining calcium and phosphorus homeostasis as well as regulating cell proliferation and diversification. Extensive burns can also lead to dysfunction of many organs, including liver and kidneys, which disturbs the vitamin D conversion into its active form. The studies conducted in vivo proved that vitamin D3 influences regulation of transforming growth factor beta and impacts development and regulation of cell growth. Vitamin D is also important for wound healing and scar tissue formation. According to up-to-date guidelines, patients that are at high risk of vitamin D deficiency can take orally even up to 10 000 IU of vitamin D daily. The safe maintenance dose amounts even up to 4000 IU daily.
- Publication
Plastic Surgery & Burns / Chirurgia Plastyczna i Oparzenia, 2016, Vol 4, Issue 3, p99
- ISSN
2300-7893
- Publication type
Article
- DOI
10.15374/ChPiO2016010