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- Title
Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.
- Authors
Stek, Cari; Shey, Muki; Mnika, Khuthala; Schutz, Charlotte; Thienemann, Friedrich; Wilkinson, Robert J; Lynen, Lutgarde; Meintjes, Graeme
- Abstract
The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
- Subjects
IMMUNE reconstitution inflammatory syndrome; PREDNISONE
- Publication
Open Forum Infectious Diseases, 2023, Vol 10, Issue 7, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofad379