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- Title
Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection.
- Authors
Song, Hongshuo; Bose, Meera; Pinyakorn, Suteeraporn; Sanders-Buell, Eric; O'Sullivan, Anne Marie; Silas, Daniel; Trichavaroj, Rapee; Nuntapinit, Bessara; Pham, Phuc T; Akapirat, Siriwat; Kroon, Eugène; Souza, Mark de; Gramzinski, Robert; Michael, Nelson L; Robb, Merlin L; Vasan, Sandhya; Tovanabutra, Sodsai; Ananworanich, Jintanat
- Abstract
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
- Subjects
HIV; VIRUS diversity; IMMUNODEFICIENCY; INFECTION
- Publication
Open Forum Infectious Diseases, 2020, Vol 7, Issue 10, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofaa429