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- Title
Treatment of asymptomatic bacteriuria in the first 2 months after kidney transplant: A controlled clinical trial.
- Authors
Antonio, Mendoza Enciso Emmanuel; Cassandra, Barajas García Carolina; Emiliano, Rodriguez Jimenez Dante; Guadalupe, Ortiz Lopez Margarita; Lilian, Reza Escalera Ana; Teresa, Tiscareño Gutiérrez María; Mario, Gonzalez Gamez; Ivan, Rodríguez Correa Gustavo; Mercedes, Ramos Velazco; Alfredo, Chew Wong; Rafael, Reyes Acevedo; Lilian, Guerrero Barrera Alma; Manuel, Arreola Guerra Jose
- Abstract
Background: The incidence of urinary tract infections (UTIs) in the first 2 months postrenal transplantation (pRT) is very high. We evaluate the efficacy of asymptomatic bacteriuria (AB) screening and treatment on the incidence of UTI in the first 2 months pRT Methods: We conducted a randomized controlled clinical trial. A urine culture was obtained in all patients on the day of the bladder catheter removal, on week three, and before removal of the ureteral catheter. The intervention group received treatment for AB. The control group did not receive treatment. The primary outcomes were the cumulative incidence of UTI and/or graft pyelonephritis and the time to the first episode of UTI and/or graft pyelonephritis Results: Eighty patients were randomized, 40 in each group, and the median follow‐up was 63 days (IQR 54–70). The average age was 29.8 years and 33.7% (n = 27) were women. The incidences of UTI (n = 10, 25 % vs. n = 4, 10%, p =.07) and pyelonephritis (n = 6, 15% vs. n = 1, 2.5%, p =.04) were greater in the intervention group, as also shown in the survival analysis: UTI (HR2.8, 95% CI 0.8–9.1, p =.07) and pyelonephritis (HR 6.5, 95% CI 0.8–54.7, p =.08), respectively. The most commonly isolated bacterium was Escherichia coli (n = 28, 59.5%), and over half were E. coli with extended‐spectrum beta‐lactamases (n = 15). A major limitation was not obtaining the calculated sample size due to a delay in patient recruitment resulting from the COVID‐19 pandemic Conclusion: Treatment of AB in the first 2 months pRT does not decrease the incidence of UTI or graft pyelonephritis and may actually increase their frequency. Routine treatment of AB during the first months after renal transplantation should not be a standard procedure.
- Subjects
CLINICAL trials; URINARY tract infections; KIDNEY transplantation; BACTERIURIA; ESCHERICHIA coli; PATIENT selection
- Publication
Transplant Infectious Disease, 2022, Vol 24, Issue 6, p1
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.13934