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- Title
Nanophotonics enhanced coverslip for phase imaging in biology.
- Authors
Wesemann, Lukas; Rickett, Jon; Song, Jingchao; Lou, Jieqiong; Hinde, Elizabeth; Davis, Timothy J.; Roberts, Ann
- Abstract
The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experimentally demonstrate a novel nanostructured coverslip that converts phase information to high-contrast intensity images. This compact device enables real-time, all-optical generation of pseudo three-dimensional images of phase objects on transmission. We show that by placing unstained human cancer cells on the device, the internal structure within the cells can be clearly seen. Our research demonstrates the significant potential of nanophotonic devices for integration into compact imaging and medical diagnostic devices.
- Publication
Light: Science & Applications, 2021, Vol 10, Issue 1, p1
- ISSN
2047-7538
- Publication type
Letter
- DOI
10.1038/s41377-021-00540-7