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- Title
Oxidative Stress, DNA Damage, and Antioxidant Enzyme Activity Induced by Hexavalent Chromium in Sprague-Dawley Rats.
- Authors
Patlolla, Anita K.; Barnes, Constance; Yedjou, Clement; Velma, V. R.; Tchounwou, Paul B.
- Abstract
This article discusses research wherein potassium dichromate was given intraperitoneally to Sprague-Dawley rats. The pertinence of such a study derives from the fact that chromium is a widespread industrial compound that is recognized as a carcinogen, mutagen and teratogen. Oxidative stress was determined through the level of reactive oxygen species (ROS), the extent of lipid peroxidation, and the activity of antioxidant enzymes in both the liver and the kidney. Single-cell gel electrophoresis was used to determine deoxyribonucleic acid (DNA) damage. It was found that the liver exhibits more antioxidant defense than the kidney.
- Subjects
POTASSIUM dichromate; HEXAVALENT chromium; SPRAGUE Dawley rats; INDUSTRIAL pollution; CARCINOGENS; MUTAGENS; TERATOGENIC agents; OXIDATIVE stress; ANTIOXIDANTS; DNA damage
- Publication
Environmental Toxicology, 2009, Vol 24, Issue 1, p66
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.20395