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- Title
Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability.
- Authors
Gradel, A. K. J.; Porsgaard, T.; Lykkesfeldt, J.; Seested, T.; Gram-Nielsen, S.; Kristensen, N. R.; Refsgaard, H. H. F.
- Abstract
Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.
- Subjects
INSULIN therapy; INSULIN absorption &; adsorption; DOSAGE forms of drugs; GLYCEMIC control; DIABETES; TREATMENT of diabetes; PROGNOSIS
- Publication
Journal of Diabetes Research, 2018, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2018/1205121