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- Title
Formulation of Ketorolac Tromethamine for Controlled Release in Gastrointestinal and Colonic Delivery System.
- Authors
Hossain, Md. Amzad; Shill, Swapon Kumar; Khan, Shakhawat Hasan; Hossen, S. M. Moazzem; Uddin, Mohammad Nasir
- Abstract
A suitable matrix system of ketorolac tromethamine (KTR) formulation has been developed with the aim of increasing the contact time, achieving controlled release, reducing the frequency of administration, improving patient compliance. In this concern an enteric-coated KTR matrix tablet intended for specific delivery of drugs to the colon by combining the use of a time dependent core with a pH-sensitive film coating. Eudragit L100, with a threshold pH 7, was selected as coating material. New formulation is proved to be noble as to KTR delivery through both gastrointestinal and colonic system. New formulation is considered to reduce gastrointestinal side effects and achieve high local drug concentration at the afflicted site in the gastrointestine and colon.
- Subjects
KETOROLAC; CONTROLLED release drugs; GASTROINTESTINAL system; PATIENT compliance; DRUG side effects
- Publication
Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia, 2018, Vol 29, Issue 2, p49
- ISSN
0126-1037
- Publication type
Article
- DOI
10.14499/indonesianjpharm29iss2pp49