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- Title
Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C.
- Authors
Antoniades, C.; Tousoulis, D.; Tountas, C.; Tentolouris, C.; Toutouza, M.; Vasiliadou, C.; Tsioufis, C.; Toutouzas, P.; Stefanadis, C.
- Abstract
Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) are both associated with endothelial dysfunction and elevated oxidative and inflammatory state. We examined the effect of vitamin C on endothelial function and levels of soluble vascular cell adhesion molecule (sVCAM-1), interleukin-6 (IL-6) and tumour necrosis factor (TNF-α), in DM patients with or without CAD and in non-diabetic subjects. Thirty-seven patients with DM + CAD, 17 patients with DM without CAD and 21 non-diabetic subjects were divided into groups receiving vitamin C 2 g/day or no anti-oxidant for 4 weeks. Forearm blood flow was determined using venous occlusion gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia was considered as index of endothelium-dependent dilation. Baseline levels of IL-6 and TNF-α were significantly higher in patients with DM + CAD compared with patients with DM ( P < 0.01) or non-diabetic subjects ( P < 0.01). IL-6 and TNF-α levels were also higher in DM compared with non-diabetic subjects ( P < 0.05). sVCAM-1 levels were lower in non-diabetic controls compared with DM + CAD ( P < 0.05) or DM ( P < 0.05). Reactive hyperaemia was higher in non-diabetic controls compared with DM + CAD ( P < 0.001) or DM ( P < 0.001). Vitamin C significantly increased reactive hyperaemia only in the DM + CAD group, while it had no effect on serum levels of sVCAM-1, TNF-α and IL-6 in any of the groups. Type 2 diabetes mellitus is associated with impaired endothelial function and increased levels of TNF-α, IL-6 and sVCAM-1, especially in patients with DM and CAD. Vitamin C significantly increased forearm vasodilatory response to reactive hyperaemia only in patients with combined DM and CAD. Diabet. Med. 21, 552–558 (2004)
- Subjects
TYPE 2 diabetes; VASCULAR endothelium; ENDOTHELIUM; OXIDATIVE stress; VITAMIN C; TUMOR necrosis factors; MEDICAL research
- Publication
Diabetic Medicine, 2004, Vol 21, Issue 6, p552
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2004.01201.x