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- Title
Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of <italic>Mycobacterium tuberculosis</italic> Infection.
- Authors
Logan, Erin; Luabeya, Angelique Kany Kany; Mulenga, Humphrey; Mrdjen, Dunja; Ontong, Cynthia; Cunningham, Adam F.; Tameris, Michele; McShane, Helen; Scriba, Thomas J.; Horsnell, William G. C.; Hatherill, Mark
- Abstract
Background: It is unclear whether antibodies can prevent <italic>Mycobacterium tuberculosis</italic> (<italic>Mtb</italic>) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and <italic>Mtb</italic> infection prevalence, defined by positive QuantiFERON (QFT) test. Methods: We studied 100 <italic>Mtb</italic> uninfected infants, aged 4–6 months. Ten infants (10%) converted to positive QFT test (QFT+) within 2 years of follow-up for <italic>Mtb</italic> infection. Antibody responses in plasma samples acquired at baseline and tuberculosis investigation were analyzed by enzyme-linked immunosorbent assay and ImmunoCAP® assay. Results: QFT− infants displayed a significant increase in total IgG titers when re-tested, compared to IgG titers at baseline, which was not observed in QFT+ infants. Bacille Calmette-Guérin (BCG) vaccine-specific IgG2 and live-attenuated measles vaccine-specific IgG were raised in QFT− infants, and infants who acquired an <italic>Mtb</italic> infection did not appear to launch a BCG-specific IgG2 response. IgG titers against the endemic helminth <italic>Ascaris lumbricoides</italic> increased from baseline to QFT re-testing in all infants. Conclusion: These data show raised IgG associates with a QFT-status. Importantly, this effect was also associated with a trend showing raised IgG titers to BCG and measles vaccine. Our data suggest a possible protective association between raised antibody titers and acquisition of <italic>Mtb</italic> infection, potentially mediated by exposure to antigens both related and unrelated to <italic>Mtb</italic>.
- Subjects
IMMUNOGLOBULIN G; MYCOBACTERIUM tuberculosis; HELMINTHIASIS
- Publication
Frontiers in Immunology, 2018, pN.PAG
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2018.01529