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- Title
HYDROGEN SULPHIDE-INDUCED HYPOTHERMIA ATTENUATES STRESS-RELATED ULCERATION IN RATS.
- Authors
Lou, Li-Xia; Geng, Bin; Du, Jun-Bao; Tang, Chao-Shu
- Abstract
1. Hydrogen sulphide (H2S) acts as a gaseous cellular messenger and has recently been reported to induce a suspended animation-like state in mice. The aim of the present study was to investigate the protective role of H2S exposure in stress gastric ulcer. 2. In the present study, we used a rat model of water immersion and restraint stress (WRS) to induce the typical stress disease, namely stress gastric ulcer. Rats were treated with WRS for 4 h, with or without pre-exposure to H2S (160 p.p.m. H2S for 2.5 h). 3. In H2S-exposed rats, body temperature was significantly reduced by 2.5C ( P < 0.01) and oxygen consumption was reduced by 37.1% ( P < 0.01) compared with control rats. Plasma levels of H2S were increased by 20.8% ( P < 0.01) following pre-exposure. Pre-exposure to H2S significantly reduced the gastric ulcer index, from 24 ± 9 to 9 ± 2 ( P < 0.01), in WRS rats. In addition, WRS increased plasma levels of adrenocorticotropin (ACTH) and corticosterone 4.7- and 4.8-fold, respectively (both P < 0.01). Pre-exposure to H2S markedly suppressed plasma ACTH and corticosterone level by 34.4 and 53.2%, respectively (both P < 0.01), and reduced WRS-elevated myeloperoxidase (MPO) activity by 19%. In the present study, WRS increased gastric malondialdehyde and conjugated diene content by 42 and 68%, respectively (both P < 0.01), and H2S exposure reduced lipid peroxide production. Finally, H2S exposure inhibited the WRS-elevated expression of glucose-regulated protein 78 and caspase 12, markers of endoplasmic reticulum stress. 4. In conclusion, a low concentration of H2S may be a new pharmacological tool for induced hypothermia to prevent severe stress-induced diseases and multifarious trauma in the clinical setting.
- Subjects
CARDIOVASCULAR disease treatment; HYDROGEN sulfide; INDUCED hypothermia; ENDOPLASMIC reticulum
- Publication
Clinical & Experimental Pharmacology & Physiology, 2008, Vol 35, Issue 2, p223
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/j.1440-1681.2007.04812.x