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- Title
Novel Platelet Function Analyzer 200 Predicts Blood Transfusion After Elective Cardiac Surgery in Patients Suspended on Dual Antiplatelet Therapy.
- Authors
Wen Cui; Jun Zhang; Yuan Wu; Weixian Yang; Runlin Gao; Yuejin Yang; Jinqing Yuan; Xueyan Zhao
- Abstract
The value of platelet function test in timing of cardiac surgery remains uncertain. Researches on correlation between Platelet Function Analyzer 200 (PFA-200) and bleeding after elective cardiac surgery are still inadequate. The objective of this study was to investigate the predictive value of PFA-200 in blood transfusion after cardiac surgery. A total of 71 patients on aspirin and P2Y12 receptor inhibitors undergoing cardiac surgery in Fuwai Hospital were enrolled. Platelet function after discontinuing of antiplatelet drugs was assessed by PFA-200 using closure time (CT). PFA-200 results before surgery were included in the statistics. The primary endpoint was postoperative blood transfusion. Seventeen patients (21.9%) received blood transfusion after cardiac surgery. The preoperative PFA-200 CT value in the transfused group was significantly higher than that in the non-transfused group (147.24± 85.54 s vs 98.06±61.59 s, P=.011). Using 106 seconds as the dividing point, the incidence of blood transfusion in the elevated PFA- 200 (CT > 106 s) group was significantly higher than those in normal PFA-200 (CT≤106 s) group (10/24 patients, 41.9% vs 7/47 patients, 14.7%, P=.012). Multivariate logistic regression analysis showed that PFA-200 CT value > 106 s was an independent predictor of postoperative blood transfusion (OR: 4.05, 95%CI: 1.19-13.86, P=.026). The platelet function test PFA-200 had a predictive value for postoperative blood transfusion in elective cardiac surgery and had a promising prospect in the timing of cardiac surgery.
- Subjects
CARDIAC surgery; BLOOD transfusion; ELECTIVE surgery; PLATELET aggregation inhibitors; CARDIAC patients; BLOOD platelet transfusion; PLATELET function tests
- Publication
Clinical & Applied Thrombosis/Hemostasis, 2023, Vol 29, p1
- ISSN
1076-0296
- Publication type
Article
- DOI
10.1177/10760296231187627