We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic evaluation of small ruminant lentivirus susceptibility in Valais blacknose sheep.
- Authors
Letko, Anna; Bützberger, Charis; Hirter, Nathalie; Paris, Julia M.; Abril, Carlos; Drögemüller, Cord
- Abstract
Maedi-Visna is a complex production-limiting ovine lentiviral disease caused by small ruminant lentivirus (SRLV) infection widespread throughout the world characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology.1 Previously, an SNP in the ovine I TMEM154 i gene (Oar rambouillet v1.0: chr 17:g.5776842G>A) as well as a short indel variant in the promoter region of ovine I CCR5 i (Oar rambouillet v1.0: chr 19:g.54980459 54980460ins) were reported as markers associated with resistance/susceptibility to SRLV in several sheep breeds globally (OMIA 001694-9940).2 SP , sp 3 Multiple other genomic regions associated with susceptibility to or control of infection were also reported indicating genetic complexity.4 In Switzerland the Valais blacknose sheep (VBS) breed was found to have the highest prevalence of Maedi-Visna among Swiss sheep breeds.5 Own analysis We collected pairs of SRLV-infected and non-infected individuals from this native Swiss sheep breed (Table S1). Conclusions No association between genotypes in the I TMEM154 i and I CCR5 i and SRLV susceptibility in the studied local Swiss breed VBS could be determined showing that these two previously reported genetic markers do not affect individual susceptibility to infection in this particular breed. For the I CCR5 i marker, 65% of cases and 73% of controls had the homozygous wild type genotype, while 26% of cases and 12% of controls were heterozygous (Table 1).
- Subjects
SHEEP breeds; SHEEP; RUMINANTS; LENTIVIRUSES; GENOME-wide association studies
- Publication
Animal Genetics, 2021, Vol 52, Issue 5, p781
- ISSN
0268-9146
- Publication type
Article
- DOI
10.1111/age.13108