We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intrapituitary Cell-Cell Communication Regulates ACTH Secretion.
- Authors
Schwartz, Jeffrey; Canny, Benedict; Vale, Wylie W.; Funder, John W.
- Abstract
Exposure of rat anterior pituitary cells in culture to a cytotoxin specific for CRF-target cells is followed by increased basal ACTH secretion from the remaining cells three days after the last exposure to the cytotoxin. When CRF-target-depleted populations are co-cultured with unexposed pituitary cells ACTH secretion is more than double that predicted in the absence of cell-to-cell interaction. These data provide evidence for an intrapituitary cell-to-cell signalling system modulating ACTH secretion. Copyright © 1989 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1989, Vol 50, Issue 6, p716
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000125304