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- Title
Tissue-Specific Regulation of Pyroglutamate Aminopeptidase II Activity by Thyroid Hormones.
- Authors
Ponce, Georgina; Charli, Jean-Louis; Pasten, Jorge A.; Aceves, Carmen; Joseph-Bravo, Patricia
- Abstract
Among the enzymes capable of degrading thyrotropin-releasing hormone (TRH) in vitro, two pyroglutamate aminopeptidases (PGA) are specific for TRH: thyroliberinase, a seric enzyme and PGAII, a membrane-bound peptidase. The effect of thyroid hormone status on the activity of these enzymes was evaluated in serum and various tissues. Only in adenohypophysis, triiodothyronine treatment increased PGAII to 376% of control; hypothyroidism produced the reverse effect (decrease to 23% of control). As previously reported, similar changes were observed for thyroliberinase. TRH degradation at the adenohypophysis level may participate in the negative feedback control of thyroid hormones. Copyright © 988_ S. Karger AG, Basel
- Publication
Neuroendocrinology, 1988, Vol 48, Issue 2, p211
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000125011