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- Title
Cutaneous lesions as initial signs of interferon α-induced sarcoidosis: report of three new cases and review of the literature.
- Authors
Fantini, Fabrizio; Padalino, Claudia; Gualdi, Giulio; Monari, Paola; Giannetti, Alberto
- Abstract
Sarcoid reactions are well-recognized adverse events during interferon (IFN) therapy. They are frequently underdiagnosed because misinterpreted as IFN-induced side effects. Sarcoid cutaneous lesions may therefore represent useful hints to an early diagnosis, but their incidence is unknown. We report three new cases of mono-localized, purely cutaneous IFNα-induced sarcoidosis. In addition, an extensive review of the literature, with special attention to skin involvement, was performed through a PubMed search. The analysis of the retrieved articles showed that cutaneous lesions are frequent signs of IFN-induced sarcoidosis. Skin involvement is documented in 56% of the reports and it appears among the presenting and diagnostic signs of a sarcoid reaction in 51%. Special attention to dermatologic signs is imperative in the course of IFN therapy because even minimal skin involvement may offer a clue to an early diagnosis of IFN-induced sarcoidosis.
- Subjects
SARCOIDOSIS; CASE studies; SKIN diseases; THERAPEUTIC complications; PRECANCEROUS conditions
- Publication
Dermatologic Therapy, 2009, Vol 22, pS1
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/j.1529-8019.2009.01263.x