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- Title
Stable Xenon Does Not Increase Intracranial Pressure in Primates with Freeze-Injury-Induced Intracranial Hypertension.
- Authors
Darby, Joseph M.; Nemoto, Edwin M.; Yonas, Howard; Melick, John
- Abstract
Summary: Stable xenon (Xe)-enhanced computed tomography is a potentially valuable tool for high resolution, three-dimensional measurement of CBF in patients. However, reports that Xe causes cerebrovascular dilation and increases intracranial pressure (ICP) have tempered enthusiasm for its use. The effects of 5 min of 33% Xe inhalation on ICP (right and left hemispheres) were studied in eight fentanyl-anesthetized Rhesus monkeys after right-sided cortical freeze injury. ICP, CBF, and physiological variables were monitored for up to 6 h postinsult. The preinjury (control) right hemispheric ICP was 8 ± 5 mm Hg (mean ± SD) and left hemispheric ICP was 5 ± 2 mm Hg. Postinjury observations were classified into low (<15 mm Hg) and high ICP (≥15 mm Hg) groups. Both right and left ICP values averaged 9 ± 3 mm Hg in the low ICP group. In the high ICP group, the right ICP was 20 ± 4 mm Hg and left ICP was 21 ± 6 mm Hg. ICP was unchanged by Xe inhalation under control conditions as well as in both low and high ICP groups postinjury. Postinjury, the MABP decreased 10-15 mm Hg in the low ICP group and 10-17 mm Hg in the high ICP group 2-3 min after the start of Xe inhalation (p < 0.05). These results show that 33% Xe inhalation does not increase ICP in fentanyl-anesthetized monkeys but could decrease MABP in stressed states, presumably because of the anesthetic effects of Xe.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1991, Vol 11, Issue 3, p522
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.1991.96