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- Title
Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma.
- Authors
Jauhiainen, Maria K.; Mohanraj, Ushanandini; Lehecka, Martin; Niemelä, Mika; Hirvonen, Timo P.; Pratas, Diogo; Perdomo, Maria F.; Söderlund-Venermo, Maria; Mäkitie, Antti A.; Sinkkonen, Saku T.
- Abstract
Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS.
- Subjects
ACOUSTIC neuroma; POLYOMAVIRUSES; PAPILLOMAVIRUSES; HERPESVIRUSES; PARVOVIRUSES; ONCOGENIC viruses
- Publication
Journal of NeuroVirology, 2023, Vol 29, Issue 2, p226
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-023-01112-8