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- Title
Predicting future left anterior descending artery events from non-culprit lesions: insights from the Lipid-Rich Plaque study.
- Authors
Kuku, Kayode O; Garcia-Garcia, Hector M; Doros, Gheorghe; Mintz, Gary S; Ali, Ziad A; Skinner, William H; Artis, Andre K; Cate, Tim ten; Powers, Eric; Wong, Shing Chiu; Wykrzykowska, Joanna; Dube, Sandeep; Kazziha, Samer; van der Ent, Martin; Shah, Priti; Sum, Stephen; Torguson, Rebecca; Mario, Carlo Di; Waksman, Ron
- Abstract
Aims The left anterior descending (LAD) artery is the most frequently affected site by coronary artery disease. The prospective Lipid Rich Plaque (LRP) study, which enrolled patients undergoing imaging of non-culprits followed over 2 years, reported the successful identification of coronary segments at risk of future events based on near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) lipid signals. We aimed to characterize the plaque events involving the LAD vs. non-LAD segments. Methods and results LRP enrolled 1563 patients from 2014 to 2016. All adjudicated plaque events defined by the composite of cardiac death, cardiac arrest, non-fatal myocardial infarction, acute coronary syndrome, revascularization by coronary bypass or percutaneous coronary intervention, and rehospitalization for angina with >20% stenosis progression and reported as non-culprit lesion-related major adverse cardiac events (NC-MACE) were classified by NIRS-IVUS maxLCBI4 mm (maximum 4-mm Lipid Core Burden Index) ≤400 or >400 and association with high-risk-plaque characteristics, plaque burden ≥70%, and minimum lumen area (MLA) ≤4 mm2. Fifty-seven events were recorded with more lipid-rich plaques in the LAD vs. left circumflex and right coronary artery; 12.5% vs. 10.4% vs. 11.3%, P = 0.097. Unequivocally, a maxLCBI4 mm >400 in the LAD was more predictive of NC-MACE [hazard ratio (HR) 4.32, 95% confidence interval (CI) (1.93–9.69); P = 0.0004] vs. [HR 2.56, 95% CI (1.06–6.17); P = 0.0354] in non-LAD segments. MLA ≤4 mm2 within the maxLCBI4 mm was significantly higher in the LAD (34.1% vs. 25.9% vs. 13.7%, P < 0.001). Conclusion Non-culprit lipid-rich segments in the LAD were more frequently associated with plaque-level events. LAD NIRS-IVUS screening may help identify patients requiring intensive surveillance and medical treatment.
- Subjects
MYOCARDIAL infarction risk factors; LIPID analysis; PUBLIC health surveillance; CONFIDENCE intervals; PERCUTANEOUS coronary intervention; ACUTE coronary syndrome; FORECASTING; CARDIAC arrest; CORONARY arteries; DISEASE risk factors
- Publication
European Heart Journal - Cardiovascular Imaging, 2022, Vol 23, Issue 10, p1365
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jeab160