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- Title
Cognitive dysfunction in patients with very mild Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on ¹⁸F-FDG PET.
- Authors
Murayama, Norio; Ota, Kazumi; Kasanuki, Koji; Kondo, Daizo; Fujishiro, Hiroshige; Fukase, Yuko; Tagaya, Hirokuni; Sato, Kiyoshi; Iseki, Eizo
- Abstract
<bold>Objective: </bold>We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography.<bold>Methods: </bold>Based on the hemispheric asymmetries of CMRglc decrease in the posterior cingulate cortex, precuneus, and parietotemporal cortex, the patients were divided into three groups (a left-dominant hypometabolism group, a right-dominant hypometabolism group, and a non-dominant hypometabolism group). CMRglc decrease in the whole brain was controlled among the three groups. All the patients underwent mini-mental state examination (MMSE), Wechsler Memory Scale-Revised (WMS-R), and Wechsler Adult Intelligent Scale-Third (WAIS-III).<bold>Results: </bold>There were no significant differences in MMSE and WAIS-III scores among the three groups. In WMS-R, the results indicated that the left-dominant group demonstrated significantly lower scores in verbal memory than the other two groups. Furthermore, the left-dominant group had a greater tendency to be diagnosed with AD rather than aMCI.<bold>Conclusions: </bold>Patients with AD and aMCI showing left-dominant hypometabolism tend to show severer impairment in verbal memory function and to be diagnosed with AD dementia.
- Subjects
ALZHEIMER'S disease research; MILD cognitive impairment; GLUCOSE; FLUORODEOXYGLUCOSE F18; AMNESIA; BRAIN metabolism; ALZHEIMER'S disease; CEREBRAL cortex; COGNITION; COGNITION disorders; DEOXY sugars; PSYCHOLOGICAL tests; RADIOPHARMACEUTICALS; POSITRON emission tomography; WECHSLER Memory Scale
- Publication
International Journal of Geriatric Psychiatry, 2016, Vol 31, Issue 1, p41
- ISSN
0885-6230
- Publication type
journal article
- DOI
10.1002/gps.4287