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- Title
Synthesis and Properties of Ag‐Au Alloy Nanoparticles with Controlled Composition for Computed Tomography Imaging Applications.
- Authors
Linh, Nguyen Thi Ngoc; Tam, Le The; Du, Nguyen Hoa; Vinh, Nguyen Dinh; Tuyet, Phan Thi Hong; Quy, Bui Minh; An, Cao Thu; Suong, Nguyen Thi; Hoa, Nguyen Thi Hong; Lu, Le Trong
- Abstract
Numerous non‐invasive assays have been developed to support CT imaging, consequently increasing the precision of diagnosis. Although these efforts made a significant contribution to clinical research, there is still more to be done. The goal is to replace conventional contrast agents with more potent ones. In this study, Ag−Au alloy nanoparticles were fabricated by substitution method between the precursor Au3+ and the previously prepared Ag nanoparticles. Effects of Au3+ quantity on the formation and characteristics of Ag−Au alloy nanoparticles were investigated. It showed that Ag−Au nanoalloy with a size of 14.2±1.0 nm, SPR absorption peak at 520 nm, and Ag: Au atomic ratio of approximately 3 : 1 were appropriate for biomedical applications. After phase transfer using poly (maleic anhydride‐alt‐1‐octadecene) (PMAO), the nano Ag−Au solution owned remarkable durability, stability and non‐toxicity Vero healthy cell line at high test concentration. In‐vitro CT imaging demonstrated a good X‐ray adsorption coefficient, and the hounsfield units (HU) was noticeably increased. As a promising CT contrast agent, the X‐ray attenuation of nano Ag−Au solutions correlated linearly with concentrations. These findings led to a potential application in the biomedical field, particularly in computed tomography (CT) imaging diagnosis.
- Subjects
COMPUTED tomography; NANOPARTICLES; CONTRAST media; ALLOYS; MEDICAL research; X-ray imaging
- Publication
ChemNanoMat, 2024, Vol 10, Issue 5, p1
- ISSN
2199-692X
- Publication type
Article
- DOI
10.1002/cnma.202300619