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- Title
Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications.
- Authors
Thao, Nguyen Thi My; Do, Hoang Dang Khoa; Nam, Nguyen Nhat; Tran, Nguyen Khoi Song; Dan, Thach Thi; Trinh, Kieu The Loan
- Abstract
Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes.
- Subjects
SYNTHETIC enzymes; ENZYME stability; GLUTATHIONE peroxidase; CATALASE; SUPEROXIDE dismutase; METAL-organic frameworks; ANTIOXIDANTS
- Publication
Micromachines, 2023, Vol 14, Issue 5, p1017
- ISSN
2072-666X
- Publication type
Article
- DOI
10.3390/mi14051017