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- Title
Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity.
- Authors
Ge, Ming-Xia; Jiang, Jian-Jun; Yang, Li-Qin; Yang, Xing-Li; He, Yong-Han; Li, Gong-Hua; Kong, Qing-Peng
- Abstract
Deep RNA sequencing of 164 blood samples collected from long-lived families was performed to investigate the expression patterns of circular RNAs (circRNAs). Unlike that observed in previous studies, circRNA expression in long-lived elderly individuals (98.3 ± 3.4 year) did not exhibit an age-accumulating pattern. Based on weighted circRNA co-expression network analysis, we found that longevous elders specifically gained eight but lost seven conserved circRNA-circRNA co-expression modules (c-CCMs) compared with normal elder controls (spouses of offspring of long-lived individuals, age = 59.3 ± 5.8 year). Further analysis showed that these modules were associated with healthy aging-related pathways. These results together suggest an important role of circRNAs in regulating human lifespan extension.
- Subjects
LONGEVITY; CIRCULAR RNA; OLDER people; BLOOD sampling
- Publication
Genes, 2022, Vol 13, Issue 5, p749
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes13050749