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- Title
Omega-3 Fatty Acids and Covid-19: Prevention or Adjuvant Therapy?
- Authors
GAMMONE, MARIA ALESSANDRA; D'ORAZIO, NICOLANTONIO
- Abstract
The mechanisms of COVID-19 complications are multifactorial, including long-term tissue damages from direct viral attack, dysregulation of both immunity and ren-in-angiotensin-aldosterone system and coagulation system, unresolved systemic inflammation and oxidative stress. Omega-3 polyunsaturated fatty acids (omega-3 or n-3 PUFAs) might have favorable effects on immunity, inflammation, oxidative stress at different stages of SARS-CoV-2 infection. Omega-3 and their metabolites including specialized proresolvin mediators, have shown effects in reducing proinflammatory cytokines, accelerating the resolution of chronic in-flammation and restoring tissue homeostasis, and therefore offer a promising strategy against COVID-19. This article will discuss the inflammatory condition during COVID-19 pandemic, fo-cus on the mechanisms that may contribute to the likely benefits of omega-3 and provide poten-tial recommendations to promote strategies for wellness.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; MYOCARDIAL depressants; FIBRINOLYTIC agents; RESPIRATORY organs; COVID-19; ANTI-inflammatory agents; RENIN-angiotensin system; DIETARY supplements; OXIDATIVE stress; OMEGA-3 fatty acids; VASODILATORS; IMMUNITY; PHARMACODYNAMICS
- Publication
Current Research in Nutrition & Food Science, 2023, Vol 11, Issue 2, p549
- ISSN
2347-467X
- Publication type
Article
- DOI
10.12944/CRNFSJ.11.2.07