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- Title
An Asynchronous Concerted Mechanism and Its Origin in Lewis Acid‐Mediated Carbonyl‐Olefin [2+2] Cycloaddition.
- Authors
Li, Yan‐Yu; Zhang, Shuo‐Qing; Hong, Xin
- Abstract
The concerted mechanism of thermal BBr3‐mediated [2+2] carbonyl‐olefin cycloaddition is intriguing considering the conflict against the Woodward–Hoffmann rule. In this work, we report a mechanistic study of the titled reaction using density functional theory calculations. The concerted [2+2] cycloaddition mechanism is operative even for the truncated model system of 2‐methyl‐2‐butene and butanone. Intrinsic reaction coordinate analysis and potential surface mapping showed the asynchronous nature of the apparent concerted [2+2] cycloaddition, resulting from the proximity of carbocation‐oxyanion in the transient zwitterionic structure. Solvent effects can change the reaction to a stepwise mechanism, highlighting the importance of zwitterion stability. Building upon this finding of the asynchronous concerted or stepwise [2+2] cycloaddition mechanism, two mechanistic classifications were elaborated based on substrates containing varied substituents and Lewis acids, with a focus on manipulating the stability of positive carbocation and negative oxyanion in the transient zwitterionic species.
- Subjects
ZWITTERIONS; CARBOCATIONS; RING formation (Chemistry); DENSITY functional theory; LEWIS acids; SURFACE potential
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 14, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202300375