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- Title
MULTIDRUG-RESISTANT URINARY TRACT ISOLATES OF ESCHERICHIA COLI: FREQUENCY AND PATIENT DEMOGRAPHICS IN A TERTIARY CARE HOSPITAL.
- Authors
Azhar, Salman; Baig, Muhmmad Wasif; Rasool, Shahid; Khan, Rizwan Rasool; Munir, Talha; Fatima, Umber; Ahsan, Muhammad
- Abstract
Urinary tract infections (UTIs) are a major burden to the health care as it is estimated that around 150 million UTIs occur yearly worldwide. Enterobacteriaceae are the most common agent causing serious urinary tract infections; and multi drug resistent (MDR) cases are increasing day by day. Objectives: To determine the frequency and patient demographics of multidrug resistant urinary tract isolates of Escherichia Coli in a Tertiary Care Hospital. Study Design: Retrospective cross sectional study. Setting: Department of Medicine, Madinah Teaching Hospital / The University of Faisalabad, Faisalabad. Period: May 2016 to Sep 2018. Material & Methods: 187 patients of age 15 to 90 years with positive E. coli on urine culture and sensitivity were included in this retrospective cross sectional study. All those patients with history of dysuria (pain during urination) or frequent urination (more than 7 times per day) were advised urine complete analysis and those with >5 WBCs or pus cells /HPF or having positive for leukocyte esterase and/or nitrite, were advised urine culture and sensitivity. Main outcome variable was the frequency of MDR cases among the culture positive E. coli UTI patients. Results: Among all the cases of E. coli UTI, frequency of MDRE UTI was 66.8% (n=125) and rest 33.2% (n= 62) cases were not MDR UTI. 97.3% patients were resistant to lactam antibiotics, 95.7% were resistant to quinolones and 68.4% were resistant to aminoglycosides. Conclusion: With the rise in the microbe’s resistance to multiple drugs, new therapeutic strategies are to be designed after analyzing our population’s susceptibility pattern. It is not less than a challenge for physicians of a developing nation like Pakistan to treat MDR E.coli UTI cases while taking care of the cost of treatment and controlling the disease burden at the same time.
- Subjects
FAISALABAD (Pakistan); PAKISTAN; URINARY organs; ESCHERICHIA coli; HOSPITAL care; BETA lactam antibiotics; TERTIARY care; URINARY tract infections
- Publication
Professional Medical Journal, 2020, Vol 27, Issue 2, p335
- ISSN
1024-8919
- Publication type
Article
- DOI
10.29309/tpmj/2020.27.02.3854