We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy and Safety of Mammalian Target of Rapamycin Inhibitors in Vascular Anomalies: A Systematic Review.
- Authors
NADAL, Marion; GIRAUDEAU, Bruno; TAVERNIER, Elsa; JONVILLE-BERA, Annie-Pierre; LORETTE, Gérard; MARUANI, Annabel
- Abstract
Mammalian target of rapamycin (mTOR) inhibitors are a promising new treatment in vascular anomalies, but no published randomized controlled trials are available. The aim of this systematic review of all reported cases was to assess the efficacy and safety of mTOR inhibitors in all vascular anomalies, except cancers, in children and adults. In November 2014 MEDLINE, CENTRAL, LILACS and EMBASE were searched for studies of mTOR inhibitors in any vascular condition, except for malignant lesions, in humans. Fourteen publications and 9 posters, with data on 25 and 59 patients, respectively, all < 18 years old were included. Of these patients, 35.7% (n = 30) had vascular tumours, and 64.3% (n = 54) had malformations. Sirolimus was the most frequent mTOR inhibitor used (98.8%, n = 83). It was efficient in all cases, at a median time of 2 weeks (95% confidence interval 1-10 weeks). Sirolimus was well tolerated, the main side-effect being mouth sores, which led to treatment withdrawal in one case. The dosage of sirolimus was heterogeneous, the most common being 1.6 mg/m2/day.
- Subjects
RAPAMYCIN; TREATMENT of vascular diseases; RANDOMIZED controlled trials; DRUG efficacy; DRUG side effects
- Publication
Acta Dermato-Venereologica, 2016, Vol 96, Issue 4, p448
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2300