We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myocardial extracellular volume derived from contrast-enhanced chest computed tomography for longitudinal evaluation of cardiotoxicity in patients with breast cancer treated with anthracyclines.
- Authors
Tu, Chunrong; Shen, Hesong; Liu, Renwei; Wang, Xing; Li, Xiaoqin; Yuan, Xiaoqian; Chen, Qiuzhi; Wang, Yu; Ran, Zijuan; Lan, Xiaosong; Zhang, Xiaoyue; Lin, Meng; Zhang, Jiuquan
- Abstract
Objectives: To assess the value of myocardial extracellular volume (ECV) derived from contrast-enhanced chest computed tomography (CT) for longitudinal evaluation of cardiotoxicity in patients with breast cancer (BC) treated with anthracycline (AC). Materials and methods: A total of 1151 patients with BC treated with anthracyclines, who underwent at least baseline, and first follow-up contrast-enhanced chest CT were evaluated. ECV and left ventricular ejection fraction (LVEF) were measured before (ECV0, LVEF0), during ((ECV1, LVEF1) and (ECV2, LVEF2)), and after (ECV3, LVEF3) AC treatment. ECV values were evaluated at the middle of left ventricular septum on venous phase images. Cancer therapy-related cardiac dysfunction (CTRCD) was recorded. Results: Mean baseline LVEF values were 65.85% ± 2.72% and 102 patients developed CTRCD. The mean ECV0 was 26.76% ± 3.03% (N0 = 1151). ECV1, ECV2, and ECV3 (median interval: 61 (IQR, 46–75), 180 (IQR, 170–190), 350 (IQR, 341–360) days from baseline) were 31.32% ± 3.10%, 29.60% ± 3.24%, and 32.05% ± 3.58% (N1 = 1151, N2 = 841, N3 = 511). ECV1, ECV2, and ECV3 were significantly higher than ECV0 (p < 0.001). ECV0 and ECV1 showed no difference between CTRCD (+) and CTRCD (−) group (p1 = 0.150; p2 = 0.216). However, ECV2 and ECV3 showed significant differences between the two groups (p3 < 0.001; p4 < 0.001). Conclusion: CT-derived ECV is a potential biomarker for dynamic monitoring AC cardiotoxicity in patients with BC.
- Subjects
ANTHRACYCLINES; CHEST examination; CANCER patients; CARDIOTOXICITY; BREAST cancer; HEART septum
- Publication
Insights into Imaging, 2022, Vol 13, Issue 1, p1
- ISSN
1869-4101
- Publication type
Article
- DOI
10.1186/s13244-022-01224-5