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- Title
Meta-analysis of TNF-α promoter −308 A/G polymorphism and SLE susceptibility.
- Authors
Young Ho Lee; Harley, John B.; Nath, Swapan K.
- Abstract
Alleles of tumor necrosis factor-α (TNF-α) gene have been inconsistently associated with systemic lupus erythematosus (SLE), particularly the 308-A/G functional promoter polymorphism. To generate large-scale evidence on whether 308-A/G promoter polymorphism is associated with SLE susceptibility we have conducted a meta-analysis. We have identified 21 studies of this polymorphism and SLE using MEDLINE search. Meta-analysis was performed for genotypes A/A (recessive effect), A/A+A/G (dominant effect), and A allele in fixed or random effects models. All control samples were in Hardy–Weinberg proportion. The overall odds ratio (OR) of the A/A genotype was 3.2 (95% CI=2.0–5.3, P<0.001). Stratification by ethnicity indicated that the A/A genotype was associated with SLE in European-derived population (OR=4.0, CI=2.5–6.4, P<0.001). No association was detected in Asian-derived population (OR, 1.3, CI=0.3–6.3, P=0.76). The overall OR for the risk genotypes (A/A and A/G) was 2.0 (CI=1.3–3.1, P<0.001). Similar results were found between the risk allele A and SLE where a significant association was found in European population (OR=2.1, CI=1.6–2.7, P<0.001), but not in Asian (OR=1.4, CI=0.8–2.3, P=0.2) or African (OR=1.2, CI=0.6–2.5, P=0.59) populations. In summary, this meta-analysis demonstrates that the TNF-α promoter −308 A/G polymorphism may confer susceptibility to SLE, especially in European-derived population.European Journal of Human Genetics (2006) 14, 364–371. doi:10.1038/sj.ejhg.5201566; published online 18 January 2006
- Subjects
META-analysis; TUMOR necrosis factors; CYTOKINES; GENETIC polymorphisms; DISEASE susceptibility; SYSTEMIC lupus erythematosus; AUTOIMMUNE diseases; VASCULAR diseases
- Publication
European Journal of Human Genetics, 2006, Vol 14, Issue 3, p364
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201566