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- Title
Occurrence of subclinical post-streptococcal glomerulonephritis in family contacts.
- Authors
Tasic, V; Polenakovic, M
- Abstract
<bold>Objective: </bold>There are few data in the published literature on the occurrence of subclinical post-streptococcal glomerulonephritis. In order to estimate the incidence of subclinical disease, 75 families of index cases with sporadic clinical post-streptococcal glomerulonephritis were screened for the presence of subclinical disease.<bold>Methods: </bold>Three hundred and seventeen family contacts were investigated 1-7 days after the admission of the index cases. The diagnosis of subclinical disease was based on the presence of abnormal urinalysis, transitory hypocomplementaemia and increased antistreptolysin O titre.<bold>Results: </bold>No cases of clinical/subclinical disease were detected among 147 parents. Abnormal urinalyses were found in 22.3% of sibling contacts. The incidence of nephritis among 170 siblings was 9.4% and the calculated ratio subclinical/clinical disease was 0.11. There were 16 siblings (9.4%) whose abnormal urinalyses could not be explained by appropriate tests; 11 of them had dysmorphic microhaematuria and significantly elevated antistreptolysin O titre.<bold>Conclusions: </bold>Sibling contacts have increased risk for the development of clinical/subclinical post-streptococcal glomerulonephritis compared with their parents. Sibling contacts with unexplained urinary abnormalities might have subclinical nephritis in evolution; their complement levels normalized before occurrence of nephritis in index cases.
- Subjects
GLOMERULONEPHRITIS; FAMILIES
- Publication
Journal of Paediatrics & Child Health, 2003, Vol 39, Issue 3, p177
- ISSN
1034-4810
- Publication type
journal article
- DOI
10.1046/j.1440-1754.2003.00106.x