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- Title
Autoantibodies to Factor XII and Kininogen-Dependent Antiphosphatidylethanolamine Antibodies in Patients with Recurrent Pregnancy Loss Augment Platelet Aggregation.
- Authors
Sato, Yoshihiro; Sugi, Toshitaka; Sakai, Rie
- Abstract
Problem Numerous studies have suggested that factor XII ( FXII) deficiency, autoantibodies to FXII (anti- FXII), and antiphosphatidylethanolamine antibodies ( aPE) are associated with recurrent pregnancy loss ( RPL). aPE in RPL patients recognize the LDC27 peptide of kininogen domain 3. Anti- FXII in RPL patients recognizes the heavy chain of FXII, especially the amino-terminal sequences IPP30 peptide. Previous studies suggested that LDC27 and IPP30 are the responsible sites competing for the same binding site on platelets and inhibiting augmentation of thrombin-induced platelet aggregation. Our aim was to study the influence of antibodies to LDC27 and IPP30 on platelet aggregation. Methods of study In fifteen healthy volunteers, platelet aggregation induced by γ-thrombin in the presence or absence of antibodies to LDC27 and IPP30 was measured. Sixteen RPL patients who were positive for anti- FXII were measured for spontaneous small platelet aggregate ( SSPA) formation. Results and Conclusions Antibodies to LDC27 and IPP30 markedly increased aggregation of normal platelets stimulated by γ-thrombin. Augmentation of SSPA formation was more frequent in the patients with RPL who were positive for anti- FXII than in the control group ( P = 0.003). This study strongly supports the hypothesis that aPE and anti- FXII may cause RPL due to disruption of the normal antithrombotic effects of kininogens and FXII.
- Subjects
AUTOANTIBODIES; BLOOD coagulation factor XIII; KININOGENS; ETHANOLAMINES; BLOOD platelet aggregation; PREGNANCY complications
- Publication
American Journal of Reproductive Immunology, 2015, Vol 74, Issue 3, p279
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12402